Method sensitivity and time-to-result are critical factors contributing to the success of a screening program for Staphylococcus aureus (SA) and methicillin-resistant Staphylococcus aureus (MRSA) infections. Time delays associated with incubation of conventional culture-based methods can delay implementation of infection control measures, requiring more general infection control measures to be used for all patients, providing opportunities for transmission. Active surveillance to identify MRSA/SA carriers is helping to mitigate the potential consequences of disease, providing relief to patients and health care institutions facing the challenges of escalating costs. 2
Only rapid techniques, such as the cobas MRSA/SA Test, enable early detection of MRSA and SA in colonized patients leading to rapid implementation of appropriate barrier precautions. The test offers microbiology labs an innovative assay that detects both organisms from a single nasal swab specimen, providing time-saving efficiencies through primary sample vial loading for lifesaving answers.
Lance R. Peterson, MD
Director of Microbiology and
Infectious Disease Research
NorthShore University HealthSystem
The cobas MRSA/SA Test is a fast, effective, and efficient way to test for both MRSA and SA in patient samples.
The cobas MRSA/SA Test:
The performance of the cobas MRSA/SA Test compared to the combination of direct and enrichment culture from 2500 evaluable results from MRSA, and from 2501 evaluable results for SA is shown below:
|MRSA: Direct and Enrichment Culture 4|
|Positive Predictive Value||71.6%|
|Negative Predictive Value||99.5%|
|SA: Direct and Enrichment Culture 4|
|Positive Predictive Value||85.3%|
|Negative Predictive Value||97.7%|
The performance of cobas MRSA/SA Test compared to initial direct culture demonstrated the following positive percent agreement and negative percent agreement:
|MRSA: Direct Culture 4|
|Positive Percentage Agreement||97.1%|
|Negative Percentage Agreement||96.9%|
|SA: Direct Culture 4|
|Positive Percentage Agreement||97.0%|
|Negative Percentage Agreement||92.1%|
The cobas MRSA/SA Test saves time with first-of-its-kind primary vial loading. Using the MSwab™ system, specimens collected on a FLOQSwab™ are transferred directly into the primary vial for testing. The MSwab system is optimized for molecular and culture applications.
Labs can run 4 to 5 small runs or 2 high-volume runs for up to 188 results/ 8 hours.
Running on the cobas 4800 System, the cobas MRSA/SA Test can process specimens using one of the fastest, most advanced real-time PCR amplification and detection methods available today. The cobas MRSA/SA Test requires up to 93% less hands-on time compared to other molecular tests for 94 samples.1
The cobas 4800 System offers flexibility with parallel sample processing capabilities. cobas MRSA/SA Test samples can be run with different tests and sample types in one run.
Run mixed batch assays of: